In this chapter, the supply chain management perspective of sustainable management is addressed. Based on the literature analysis, we develop a qualitative adaptive framework for sustainable supply networks that is composed of the integrated elements of environment management, operations economic development and information technologies, product life-cycle management, and social development. Subsequently, we develop a quantitative adaptive framework for sustainable supply networks. As sustainable systems are designed to support decisions on planning, analysis and improving organization’s actions and operations to meet competitiveness and sustainability goals, it becomes necessary to interconnect the stages of supply network planning and execution. Indeed, as supply network are not static but highly dynamic and permanently evolving systems, sustainability of these network should also be considered as a dynamic category of suuply chain (SC) adaptive evolution. Mathematical framework is based on a combined applications of operations research and modern control theory. Finally, we address the issue of interrelating environment and economic sustainability and propose to consider the SC property to achieve a balance between the economic output performance and resource consumption as the SC global stability. The proposed framework can be employed as a competitive strategy to increase organizations’ wealth and sustainability by producing demand-corresponding products in a cost-effective manner through an increase of SC agility, resilience, stability, and adaptation capalities.