The analysis of the assessment methods of modern supply chain networks’ (SCN) resilience while managing their configuration and reconfiguration under the conditions of predictable disruptions has shown that under the conditions of unpredictable disruptions these methods are not acceptable. In addition, these are not acceptable in case of the design and creation of SCNs, which are completely different in composition and structure from the known SCNs. This situation requires the development of conceptually new methodological foundations for assessing the SCN’s resilience and analyzing such an important characteristic of SCN as structural resilience’s configuration. The article presents possible ways of assessing the SCN’s configurations of structural resilience, which depict the implementation of their own functions by elements and key nodes of the SCN as well as their participation in the production and technological processes of supply chain management.